Genetic risk of prostate cancer in Ugandan men.

ABSTRACT:

Background

Men of African-ancestry have elevated prostate cancer (PCa) incidence and mortality compared to men of other racial groups. There is support for a genetic contribution to this disparity, with evidence of genetic heterogeneity in the underlying risk alleles between populations. Studies of PCa among African men may inform the contribution of genetic risk factors to the elevated disease burden in this population.

Methods

We conducted an association study of >100 previously reported PCa risk alleles among 571 incidence cases and 485 controls among Uganda men. Unconditional logistic regression was used to test genetic associations and a polygenic risk score (PRS) was derived to assess the cumulative effect of the known risk alleles in association with PCa risk. In an e

SUBMITTER: Du Z 

PROVIDER: S-EPMC7534689 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature