Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation.

ABSTRACT:

Background

Relationships between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation have been described in single-center studies. Geographic variations in the composition of human microbial communities and differences in clinical practices across institutions raise the question of whether these associations are generalizable.

Methods

The microbiota composition of fecal samples obtained from patients who were undergoing allogeneic hematopoietic-cell transplantation at four centers was profiled by means of 16S ribosomal RNA gene sequencing. In an observational study, we examined associations between microbiota diversity and mortality using Cox proportional-hazards analysis. For stratification of the cohorts into higher- and lower-d

SUBMITTER: Peled JU 

PROVIDER: S-EPMC7534690 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature