Hypofractionated radiation therapy for basal and squamous cell skin cancer: A meta-analysis.

ABSTRACT:

Purpose

To characterize the cosmetic outcomes and local recurrence (LR) rates of various hypofractionated radiation therapy (RT) regimens for skin basal and squamous cell cancers (BCCs/SCCs).

Methods

A PICOS/PRISMA/MOOSE selection protocol was performed to identify 344 articles published between 1985-2016 evaluating patients with T1-2 N0 SCCs/BCCs treated with definitive RT. Biologically equivalent doses with α/β=3 (BED₃s) were calculated. The primary endpoint was post-treatment cosmesis. Mixed effects regression models were used to estimate weighted linear relationships between BED₃ and cosmetic outcomes.

Results

A total of 21 studies were identified detailing the treatment of 9729 skin BCC/SCC patients, across seven countries, with external bea

SUBMITTER: Zaorsky NG 

PROVIDER: S-EPMC7534946 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature