Factors influencing decline in quality of life in smokers without airflow obstruction: The COPDGene study.

ABSTRACT:

Introduction

Current and former smokers with normal spirometry and with Preserved Ratio Impaired Spirometry (PRISm) experience respiratory events similar to chronic obstructive pulmonary disease (COPD) exacerbations. Exacerbations significantly reduce quality of life (QoL) in COPD patients however the effect of respiratory exacerbations on QoL in these groups is unknown. We hypothesized that exacerbations and change in exacerbation status would predict QoL decline among normal spirometry and PRISm participants in COPDGene.

Methods

COPDGene is a multicenter, longitudinal study in the U.S. designed to identify genetic determinants of COPD. We enrolled study subjects in Phase 1 of COPDGene and performed multivariable logistic regression models to determine independent predictor

SUBMITTER: Parekh TM 

PROVIDER: S-EPMC7534974 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature