Higher level of acute serum VEGF and larger infarct volume are more frequently associated with post-stroke cognitive impairment.

ABSTRACT:

Background

Serum vascular endothelial growth factor (VEGF) and infarct volume detected by brain imaging have been associated with stroke outcome. However, the relationship of these two variables with post-stroke cognitive impairment (PSCI) remains unclear. We aimed to investigate the association between acute serum VEGF levels and infarct volume with PSCI in ischemic stroke patients.

Methods

Fifty-six first-ever ischemic stroke patients who were hospitalized in Dr. Sardjito General Hospital Yogyakarta, Indonesia were prospectively recruited. Serum VEGF level was taken on day 5 of stroke onset and measured by ELISA. Infarct volume was calculated manually from head CT scan by expert radiologist. PSCI was assessed after 3 months follow up by using Montreal Cognitive Assessment-

SUBMITTER: Prodjohardjono A 

PROVIDER: S-EPMC7535035 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature