Comparative test-retest variability of outcome parameters derived from brain [18F]FDG PET studies in non-human primates.

ABSTRACT:

Introduction

Knowledge of the repeatability of quantitative parameters derived from [18F]FDG PET images is essential to define the group size and allow correct interpretation. Here we tested repeatability and accuracy of different [18F]FDG absolute and relative quantification parameters in a standardized preclinical setup in nonhuman primates (NHP).

Material and methods

Repeated brain [18F]FDG scans were performed in 6 healthy NHP under controlled experimental factors likely to account for variability. Regional cerebral metabolic rate of glucose (CMRglu) was calculated using a Patlak plot with blood input function Semi-quantitative approaches measuring standard uptake values (SUV, SUV×glycemia and SUVR (SUV Ratio) using the pons or cerebellum as a reference region) were cons

SUBMITTER: Goutal S 

PROVIDER: S-EPMC7535063 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature