Long-term ozone exposure is positively associated with telomere length in critically ill patients.

ABSTRACT:

Rationale

Chronic air pollutant exposure has been associated with development of Acute Respiratory Distress Syndrome (ARDS) in patients at risk, particularly from severe trauma. We recently reported that shorter peripheral blood leukocyte (PBL) telomere length (TL) was associated with worse outcomes and higher severity of ARDS in critically ill patients. Since most major air pollutants are potent oxidants that can induce cellular oxidative stress, and oxidative stress can accelerate telomere shortening, we hypothesized that higher levels of chronic air pollutant exposure would be associated with shorter telomere length in critically ill patients including patients with ARDS.

Methods

PBL-TL was measured in genomic DNA collected on the morning of ICU day 2 in 772 critically il

SUBMITTER: Wang C 

PROVIDER: S-EPMC7535086 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature