MTHFR polymorphisms (rs1801133) and systemic lupus erythematosus risk: A meta-analysis.

ABSTRACT:

Background

The relationship between MTHFR (5, 10-methylene tetrahydrofolate reductase) gene polymorphisms and Systemic Lupus Erythematosus (SLE) has been wildly studied, but the results are still conflicting. Therefore, the purpose of this meta and pooled analysis was to identify the role of the MTHFR SNP (single nucleotide polymorphism, rs1801133) in SLE in a large sample of subjects and to assess the risk of SLE.

Methods

Data were collected from EMBASE, PubMed and China National Knowledge Infrastructure from inception to August, 2019. Summary odds ratio (OR) with 95% confidence interval (CI) was applied to assess the association. Subgroup and sensitivity analysis were performed to assess the potential sources of heterogeneity of the pooled estimation.

Results

We ide

SUBMITTER: Zhou HY 

PROVIDER: S-EPMC7535654 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature