Term Matrix: a novel Gene Ontology annotation quality control system based on ontology term co-annotation patterns.

ABSTRACT: Biological processes are accomplished by the coordinated action of gene products. Gene products often participate in multiple processes, and can therefore be annotated to multiple Gene Ontology (GO) terms. Nevertheless, processes that are functionally, temporally and/or spatially distant may have few gene products in common, and co-annotation to unrelated processes probably reflects errors in literature curation, ontology structure or automated annotation pipelines. We have developed an annotation quality control workflow that uses rules based on mutually exclusive processes to detect annotation errors, based on and validated by case studies including the three we present here: fission yeast protein-coding gene annotations over time; annotations for cohesin complex subunits in human and mo

SUBMITTER: Wood V 

PROVIDER: S-EPMC7536087 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature