SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals.

ABSTRACT: SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To enter host cells, the viral spike protein (S-protein) binds to its receptor, ACE2, and is then processed by TMPRSS2. Whilst receptor binding contributes to the viral host range, S-protein:ACE2 complexes from other animals have not been investigated widely. To predict infection risks, we modelled S-protein:ACE2 complexes from 215 vertebrate species, calculated changes in the energy of the complex caused by mutations in each species, relative to human ACE2, and correlated these changes with COVID-19 infection data. We also analysed structural interactions to better understand the key residues contributing to affinity. We predict that muta

SUBMITTER: Lam SD 

PROVIDER: S-EPMC7536205 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature