DNA methylation signature of passive smoke exposure is less pronounced than active smoking: The Understanding Society study.

ABSTRACT:

Introduction

The extent of the biological impact of passive smoke exposure is unclear. We sought to investigate the association between passive smoke exposure and DNA methylation, which could serve as a biomarker of health risk.

Materials and methods

We derived passive smoke exposure from self-reported questionnaire data among smoking and non-smoking partners of participants enrolled in the UK Household Longitudinal Study 'Understanding Society' (n=769). We performed an epigenome-wide association study (EWAS) of passive smoke exposure with DNA methylation in peripheral blood measured using the Illumina Infinium Methylation EPIC array.

Results

No CpG sites surpassed the epigenome-wide significance threshold of p<5.97 × 10^-8 in relation to partner smoking, co

SUBMITTER: Hulls PM 

PROVIDER: S-EPMC7536273 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature