Polarized Light Imaging of the Myoarchitecture in Tetralogy of Fallot in the Perinatal Period.

ABSTRACT: Background: The pathognomonic feature of tetralogy of Fallot (ToF) is the antero-cephalad deviation of the outlet septum in combination with an abnormal arrangement of the septoparietal trabeculations. Aims: The aim of this article was to study perinatal hearts using Polarized Light Imaging (PLI) in order to investigate the deep alignment of cardiomyocytes that bond the different components of the ventricular outflow tracts both together and to the rest of the ventricular mass, thus furthering the classic description of ToF. Methods and Materials: 10 perinatal hearts with ToF and 10 perinatal hearts with no detectable cardiac anomalies (control) were studied using PLI. The orientation of the myocardial cells was extracted and studied at high resolution. Virtual dissect

SUBMITTER: Truong BL 

PROVIDER: S-EPMC7536283 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature