Comparison of patient stratification by computed tomography radiomics and hypoxia positron emission tomography in head-and-neck cancer radiotherapy.

ABSTRACT:

Background and purpose

Hypoxia Positron-Emission-Tomography (PET) as well as Computed Tomography (CT) radiomics have been shown to be prognostic for radiotherapy outcome. Here, we investigate the stratification potential of CT-radiomics in head and neck cancer (HNC) patients and test if CT-radiomics is a surrogate predictor for hypoxia as identified by PET.

Materials and methods

Two independent cohorts of HNC patients were used for model development and validation, HN1 (n = 149) and HN2 (n = 47). The training set HN1 consisted of native planning CT data whereas for the validation cohort HN2 also hypoxia PET/CT data was acquired using [¹⁸F]-Fluoromisonidazole (FMISO). Machine learning algorithms including feature engineering and classifier selection were trained fo

SUBMITTER: Socarras Fernandez JA 

PROVIDER: S-EPMC7536307 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature