Methods and implementation of a pediatric asthma pharmacogenomic study in the emergency department setting.

ABSTRACT:

Objectives

The emergency department (ED) is a challenging setting to conduct pharmacogenomic studies and integrate that data into fast-paced and potentially life-saving treatment decisions. Therefore, our objective is to present the methods and feasibility of a pilot pharmacogenomic study set in the ED that measured pediatric bronchodilator response (BDR) during acute asthma exacerbations.

Methods

This is an exploratory pilot study that collected buccal swabs for DNA and measured BDR during ED encounters for pediatric asthma exacerbations. We evaluated the study's feasibility with a qualitative analysis of ED provider surveys and quantitatively by the proportion of eligible patients enrolled.

Results

We enrolled 59 out of 90 patients (65%) that were identified and con

SUBMITTER: Fishe JN 

PROVIDER: S-EPMC7536354 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature