Association of DRD2 gene polymorphisms with schizophrenia in the young Bangladeshi population: A pilot study.

ABSTRACT:

Purpose

DRD2 gene is considered one of the most important candidate genes for the schizophrenia (SCZ) development due to its role in dopamine signaling and no genetic association study has been conducted yet on the Bangladeshi SCZ patients. The objective of the present study was to investigate the association of DRD2 genetic polymorphisms (rs4648317, rs4936270, and rs7131056) with SCZ in the Bangladeshi population.

Patients and methods

This case-control study consisted of 101 SCZ patients and 101 controls. Genotyping was performed by the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.

Results

The average ages were 22.15 and 22.09 years in patients and controls, respectively (p > 0.05). CT genotype of rs4936270 showed a signifi

SUBMITTER: Hussain MS 

PROVIDER: S-EPMC7536371 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature