Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells.

ABSTRACT: Cell division cycle 6 (Cdc6) plays key roles in regulating DNA replication, and activation and maintenance of cell cycle check points. In addition, Cdc6 exerts oncogenic properties via genomic instability associated with incomplete DNA replication. This study aimed to examine the effects of Cdc6 on pancreatic cancer (PC) cells. Our results showed that Cdc6 expression was higher in clinical PC specimens (based on analysis of the GEPIA database) and cell lines, and the high Cdc6 expression was associated with poorer survival in The Cancer Genome Atlas-PC cohort. In addition, Cdc6-depleted PC cells significantly inhibited cell proliferation and colony formation, delayed G₂/M cell cycle progression, and increased expression of p-histone H3 and cyclin A2 levels. These observations co

SUBMITTER: Youn Y 

PROVIDER: S-EPMC7536414 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature