Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study.

ABSTRACT:

Background & aims

Chronic liver disease (CLD) and cirrhosis are associated with immune dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes following SARS-CoV-2 infection. We aimed to determine the impact of COVID-19 on patients with pre-existing liver disease, which currently remains ill-defined.

Methods

Between 25th March and 8th July 2020, data on 745 patients with CLD and SARS-CoV-2 (including 386 with and 359 without cirrhosis) were collected by 2 international registries and compared to data on non-CLD patients with SARS-CoV-2 from a UK hospital network.

Results

Mortality was 32% in patients with cirrhosis compared to 8% in those without (p <0.001). Mortality in patients with cirrhosis increased according to Child-Pugh cla

SUBMITTER: Marjot T 

PROVIDER: S-EPMC7536538 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature