Visual Sequences Drive Experience-Dependent Plasticity in Mouse Anterior Cingulate Cortex.

ABSTRACT: Mechanisms of experience-dependent plasticity have been well characterized in mouse primary visual cortex (V1), including a form of potentiation driven by repeated presentations of a familiar visual sequence ("sequence plasticity"). The prefrontal anterior cingulate cortex (ACC) responds to visual stimuli, yet little is known about if and how visual experience modifies ACC circuits. We find that mouse ACC exhibits sequence plasticity, but in contrast to V1, the plasticity expresses as a change in response timing, rather than a change in response magnitude. Sequence plasticity is absent in ACC, but not V1, in a mouse model of a neurodevelopmental disorder associated with intellectual disability and autism-like features. Our results demonstrate that simple sensory stimuli can be used to reve

SUBMITTER: Sidorov MS 

PROVIDER: S-EPMC7536640 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature