Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase.

ABSTRACT: The cGMP-dependent protein kinase in Plasmodium falciparum (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new antimalarial agents. Existing inhbitors, while potent and active in malaria models are not optimal. This communication describes initial optimization of a structurally distinct class of PfPKG inhibitors.

SUBMITTER: Mahmood SU 

PROVIDER: S-EPMC7536641 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature