Genome-wide Study Identifies Association between HLA-B^∗55:01 and Self-Reported Penicillin Allergy.

ABSTRACT: Hypersensitivity reactions to drugs are often unpredictable and can be life threatening, underscoring a need for understanding their underlying mechanisms and risk factors. The extent to which germline genetic variation influences the risk of commonly reported drug allergies such as penicillin allergy remains largely unknown. We extracted data from the electronic health records of more than 600,000 participants from the UK, Estonian, and Vanderbilt University Medical Center's BioVU biobanks to study the role of genetic variation in the occurrence of self-reported penicillin hypersensitivity reactions. We used imputed SNP to HLA typing data from these cohorts to further fine map the human leukocyte antigen (HLA) association and replicated our results in 23andMe's research cohort involving a

SUBMITTER: Krebs K 

PROVIDER: S-EPMC7536643 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature