IgE-Mediated Immune Response and Antibody-Mediated Rejection.

ABSTRACT:

Background and objectives

Active antibody-mediated rejection is the main cause of kidney transplant loss, sharing with SLE the alloimmune response and the systemic activation of the IFN-α pathway. IgE-mediated immune response plays a key role in the development of SLE nephritis and is associated with IFN-α secretion. The aim of our study was to investigate IgE-mediated immune response in antibody-mediated rejection.

Design, setting, participants, & measurements

This was a cross-sectional study of 56 biopsy-proven antibody-mediated rejection study participants, 80 recipients with normal graft function/histology (control), 16 study participants with interstitial fibrosis/tubular atrophy, and six participants with SLE. We evaluated graft IgE deposition, tryptase (

SUBMITTER: Rascio F 

PROVIDER: S-EPMC7536744 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature