Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are known to contribute to immune evasion in cancer. However, the function of the human granulocytic (G)-MDSC subset during tumor progression is largely unknown, and there are no established markers for their identification in human tumor specimens. Using gene expression profiling, mass cytometry, and tumor microarrays, we here demonstrate that human G-MDSCs occur as neutrophils at distinct maturation stages, with a disease-specific profile. G-MDSCs derived from patients with metastatic breast cancer and malignant melanoma display a unique immature neutrophil profile, that is more similar to healthy donor neutrophils than to G-MDSCs from sepsis patients. Finally, we show that primary G-MDSCs from metastatic breast cancer patients co-transplanted wit

SUBMITTER: Mehmeti-Ajradini M 

PROVIDER: S-EPMC7536824 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature