Innate immunity during SARS-CoV-2: evasion strategies and activation trigger hypoxia and vascular damage.

ABSTRACT: Innate immune sensing of viral molecular patterns is essential for development of antiviral responses. Like many viruses, SARS-CoV-2 has evolved strategies to circumvent innate immune detection, including low cytosine-phosphate-guanosine (CpG) levels in the genome, glycosylation to shield essential elements including the receptor-binding domain, RNA shielding and generation of viral proteins that actively impede anti-viral interferon responses. Together these strategies allow widespread infection and increased viral load. Despite the efforts of immune subversion, SARS-CoV-2 infection activates innate immune pathways inducing a robust type I/III interferon response, production of proinflammatory cytokines and recruitment of neutrophils and myeloid cells. This may induce hyperinflammation or

SUBMITTER: Amor S 

PROVIDER: S-EPMC7537271 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature