CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy.

ABSTRACT:

Background

Immunotherapy has achieved remarkable advances via a variety of strategies against tumor cells that evade immune surveillance. As important innate immune cells, macrophages play important roles in maintaining homeostasis, preventing pathogen invasion, resisting tumor cells and promoting adaptive immune response. CD47 is found to be overexpressed on tumor cells and act as a don't eat me' signal, which contributes to immune evasion. Macrophages mediated phagocytosis via blockade CD47/SIRPα (signal regulatory protein alpha) interaction was proved to induce effective antitumor immune response.

Methods

A novel peptide pep-20, specifically targeting CD47 and blocking CD47/SIRPα interaction, was identified via high-throughput phage display library bio-panning. The capabi

SUBMITTER: Wang H 

PROVIDER: S-EPMC7537338 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature