Local Control and Toxicity of External Beam Reirradiation With a Pulsed Low-dose-rate Technique.

ABSTRACT:

Purpose

To evaluate the efficacy and toxicity of external beam reirradiation using a pulsed low-dose-rate (PLDR) technique.

Methods and materials

We evaluated patients treated with PLDR reirradiation from 2009 to 2016 at a single institution. Toxicity was graded using the Common Terminology Criteria for Adverse Events, version 4.0, and local control was assessed using the Response Evaluation Criteria In Solid Tumors, version 1.1. On univariate analysis (UVA), the χ² and Fisher exact tests were used to assess the toxicity outcomes. Competing risk analysis using cumulative incidence function estimates were used to assess local progression.

Results

A total of 39 patients were treated to 41 disease sites with PLDR reirradiation. These patients had a median foll

SUBMITTER: Lee CT 

PROVIDER: S-EPMC7537409 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature