Antihypertensive therapies in moderate or severe aortic stenosis: a systematic review and meta-analysis.

ABSTRACT:

Background

Hypertension confers a poor prognosis in moderate or severe aortic stenosis (AS), however, antihypertensive therapy (AHT) is often not prescribed due to the perceived deleterious effects of vasodilation and negative inotropes.

Objective

To assess the efficacy and safety outcomes of AHT in adults with moderate or severe AS.

Design

Systematic review and meta-analysis.

Data sources

The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and grey literature were searched without language restrictions up to 9 September 2019.

Study eligibility criteria, appraisal and synthesis methods

Two independent reviewers performed screening, data extraction and risk of bias assessments from a systematic search of observational studies and randomise

SUBMITTER: Sen J 

PROVIDER: S-EPMC7537451 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature