Accuracy of potential diagnostic indicators for coeliac disease: a systematic review protocol.

ABSTRACT:

Introduction

Coeliac disease (CD) is a systemic immune-mediated disorder triggered by gluten in genetically predisposed individuals. CD is diagnosed using a combination of serology tests and endoscopic biopsy of the small intestine. However, because of non-specific symptoms and heterogeneous clinical presentation, diagnosing CD is challenging. Early detection of CD through improved case-finding strategies can improve the response to a gluten-free diet, patients' quality of life and potentially reduce the risk of complications. However, there is a lack of consensus in which groups may benefit from active case-finding.

Methods and analysis

We will perform a systematic review to determine the accuracy of diagnostic indicators (such as symptoms and risk factors) for CD in adults

SUBMITTER: Elwenspoek MMC 

PROVIDER: S-EPMC7537462 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature