Heat Shock Alters Mesenchymal Stem Cell Identity and Induces Premature Senescence.

ABSTRACT: Heat stress can have a serious impact on the health of both humans and animals. A major question is how heat stress affects normal development and differentiation at both the cellular and the organism levels. Here we use an in vitro experimental system to address how heat shock treatment influences the properties of bovine mesenchymal stem cells (MSCs)-multipotent progenitor cells-which are found in most tissues. Because cattle are sensitive to harsh external temperatures, studying the effects of heat shock on MSCs provides a unique platform to address cellular stress in a physiologically relevant model organism. Following isolation and characterization of MSCs from the cow's umbilical cord, heat shock was induced either as a pulse (1 h) or continuously (3 days), and consequent effe

SUBMITTER: Shimoni C 

PROVIDER: S-EPMC7537765 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature