Testing the face validity and inter-rater agreement of a simple approach to drug-drug interaction evidence assessment.

ABSTRACT: Low concordance between drug-drug interaction (DDI) knowledge bases is a well-documented concern. One potential cause of inconsistency is variability between drug experts in approach to assessing evidence about potential DDIs. In this study, we examined the face validity and inter-rater reliability of a novel DDI evidence evaluation instrument designed to be simple and easy to use.

Methods

A convenience sample of participants with professional experience evaluating DDI evidence was recruited. Participants independently evaluated pre-selected evidence items for 5 drug pairs using the new instrument. For each drug pair, participants labeled each evidence item as sufficient or insufficient to establish the existence of a DDI based on the evidence categories provided by the instrument.

SUBMITTER: Grizzle AJ 

PROVIDER: S-EPMC7537787 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature