A protocol for the development and internal validation of a model to predict clinical response to antihistamines in urticaria patients.

ABSTRACT: Chronic urticaria causes a significant limitation to quality of life. In the literature, various studies can be found that have reviewed several clinical and laboratory markers, but none of these variables alone is sufficient to predict the patient's prognosis. In this study, we present a protocol to develop a prognostic model that can predict the clinical response of urticaria patients to antihistamines. This is a protocol for a bidirectional cohort study. Urticaria data will be routinely collected from a population of patients over 18 years old. A full multivariable logistic regression model will be fitted, following five steps: 1) Selection of predictive variables for the model; 2) Evaluation of the quality of the collected data and control of lost data; 3) Data statistical management;

SUBMITTER: Sanchez J 

PROVIDER: S-EPMC7537877 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature