Buffering and total calcium levels determine the presence of oscillatory regimes in cardiac cells.

ABSTRACT: Calcium oscillations and waves induce depolarization in cardiac cells which are believed to cause life-threathening arrhythimas. In this work, we study the conditions for the appearance of calcium oscillations in both a detailed subcellular model of calcium dynamics and a minimal model that takes into account just the minimal ingredients of the calcium toolkit. To avoid the effects of homeostatic changes and the interaction with the action potential we consider the somewhat artificial condition of a cell without pacing and with no calcium exchange with the extracellular medium. Both the full subcellular model and the minimal model present the same scenarios depending on the calcium load: two stationary states, one with closed ryanodine receptors (RyR) and most calcium in the cell stored in

SUBMITTER: Marchena M 

PROVIDER: S-EPMC7537911 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature