Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review.

ABSTRACT:

Background

Animal models of COVID-19 have been rapidly reported after the start of the pandemic. We aimed to assess whether the newly created models reproduce the full spectrum of human COVID-19.

Methods

We searched the MEDLINE, as well as BioRxiv and MedRxiv preprint servers for original research published in English from January 1 to May 20, 2020. We used the search terms (COVID-19) OR (SARS-CoV-2) AND (animal models), (hamsters), (nonhuman primates), (macaques), (rodent), (mice), (rats), (ferrets), (rabbits), (cats), and (dogs). Inclusion criteria were the establishment of animal models of COVID-19 as an endpoint. Other inclusion criteria were assessment of prophylaxis, therapies, or vaccines, using animal models of COVID-19.

Result

Thirteen peer-reviewed studies a

SUBMITTER: Ehaideb SN 

PROVIDER: S-EPMC7537968 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature