The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series.

ABSTRACT: Convalescent plasma (CP) transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections. However, the quality control of CP and individual variation in patients in different studies make it rather difficult to evaluate the efficacy and risk of CP therapy for coronavirus disease 2019 (COVID-19). We aimed to explore the potential efficacy of CP therapy, and to assess the possible factors associated with its efficacy. We enrolled eight critical or severe COVID-19 patients from four centers. Each patient was transfused with 200-400 mL of CP from seven recovered donors. The primary indicators for clinical efficacy assessment were the changes of clinical symptoms, laboratory parameters, and radiological image after CP transfusion. CP donors had a wide

SUBMITTER: Zeng H 

PROVIDER: S-EPMC7538052 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature