Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus.

ABSTRACT: Large, longitudinal studies on androgen levels in pregnant women with polycystic ovary syndrome (PCOS) are lacking. While metformin has a mild androgen-lowering effect in non-pregnant women with PCOS, its effects on maternal androgen levels in pregnancy are less well understood. To describe androgen patterns in pregnant women with PCOS and in healthy control women, and to explore the potential effects of metformin on maternal androgen levels in PCOS. A post hoc analysis from a randomized, placebo-controlled, multicenter study carried out at 11 secondary care centers and a longitudinal single-center study on healthy pregnant women in Norway. A total of 262 women with PCOS and 119 controls. The participants with PCOS were randomly assigned to metformin (2 g daily) or placebo, from first trim

SUBMITTER: Andræ F 

PROVIDER: S-EPMC7538101 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature