Genetic Variation and Hot Flashes: A Systematic Review.

ABSTRACT:

Context

Approximately 70% of women report experiencing vasomotor symptoms (VMS, hot flashes and/or night sweats). The etiology of VMS is not clearly understood but may include genetic factors.

Evidence acquisition

We searched PubMed and Embase in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance. We included studies on associations between genetic variation and VMS. We excluded studies focused on medication interventions or prevention or treatment of breast cancer.

Evidence synthesis

Of 202 unique citations, 18 citations met the inclusion criteria. Study sample sizes ranged from 51 to 17 695. Eleven of the 18 studies had fewer than 500 participants; 2 studies had 1000 or more. Overall, statistically significant association

SUBMITTER: Crandall CJ 

PROVIDER: S-EPMC7538102 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature