Persisting Muscle Dysfunction in Cushing's Syndrome Despite Biochemical Remission.

ABSTRACT: Glucocorticoid-induced myopathy is a characteristic symptom of endogenous Cushing's syndrome (CS). Its long-term outcome is largely unknown. To evaluate long-term muscle function following the remission of endogenous CS. Observational longitudinal cohort study. Tertiary care hospitals and a specialized outpatient clinic. As part of the prospective multicenter German Cushing's Registry, we assessed muscle strength in patients with overt endogenous CS. We studied the patients at the time of diagnosis (n = 88), after 6 months (n = 69), and thereafter annually, following surgical remission over a period of up to 4 years (1 year: n = 55; 2 years: n = 34; 3 years: n = 29; 4 years: n = 22). Muscle function was evaluated by hand grip strength and by chair rising test. Grip strength was decreased t

SUBMITTER: Vogel F 

PROVIDER: S-EPMC7538105 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature