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Identification of novel mutations in SARS-COV-2 isolates from Turkey.

ABSTRACT: SARS-CoV-2 was first detected in the city of Wuhan, Hubei Province, China. In this study, we identified 11 unique mutations in viral SARS-COV-2 isolates from Turkey. Nine of them cause structural alterations in the S protein, nsp2, nsp3, nsp4 and nsp12 regions. The mutations identified here might have significant functional implications that need to be addressed in future studies in the context of vaccine engineering and therapeutic interventions. Moreover, transmission and phylogenetic analysis revealed multiple independent sources of introductions of SARS-CoV-2 into Turkey and a close relationship to the isolates from Saudi Arabia.

SUBMITTER: Rehman S

PROVIDER: S-EPMC7538173 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Identification of novel mutations in SARS-COV-2 isolates from Turkey.

Rehman Shazia S Mahmood Tariq T Aziz Ejaz E Batool Riffat R

Archives of virology 20201006 12

SARS-CoV-2 was first detected in the city of Wuhan, Hubei Province, China. In this study, we identified 11 unique mutations in viral SARS-COV-2 isolates from Turkey. Nine of them cause structural alterations in the S protein, nsp2, nsp3, nsp4 and nsp12 regions. The mutations identified here might have significant functional implications that need to be addressed in future studies in the context of vaccine engineering and therapeutic interventions. Moreover, transmission and phylogenetic analysis ...[more]

PMID: 33025199

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