Emulating a target trial of statin use and risk of dementia using cohort data.

ABSTRACT:

Objective

Observational data can be used to attempt to emulate a target trial of statin use and estimate analogues of intention-to-treat and per protocol effects on dementia risk.

Methods

Using data from a prospective cohort study in the Netherlands, we conceptualized a sequence of "trials" in which eligible individuals ages 55-80 years were classified as statin initiators or noninitiators for every consecutive month between 1993 and 2007 and were followed until diagnosis of dementia, death, loss to follow-up, or the end of follow-up. We estimated 2 types of effects of statin use on dementia and a combined endpoint of dementia or death: the effect of initiation vs no initiation and the effect of sustained use vs no use. We estimated risk by statin treatment strategy over tim

SUBMITTER: Caniglia EC 

PROVIDER: S-EPMC7538212 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature