Mean platelet volume and its genetic variants relate to stroke severity and 1-year mortality.

ABSTRACT:

Objective

To determine whether mean platelet volume (MPV) and selected single nucleotide polymorphisms (SNPs) that have been associated with MPV in genome-wide association studies relate to stroke severity, functional outcome on discharge, and 1-year mortality in patients with ischemic stroke, we retrospectively analyzed 577 patients with first-ever ischemic stroke.

Methods

Genotyping of 3 SNPs (rs342293, rs1354034, rs7961894) was performed using a real-time PCR allelic discrimination assay. Multivariable regression was used to determine the association of MPV and MPV-associated SNPs with the NIH Stroke Scale (NIHSS) score on admission, modified Rankin Scale score on discharge, and data on 1-year mortality.

Results

Rs7961894, but not rs342293 or rs1354034 SNP, was ind

SUBMITTER: Miller MM 

PROVIDER: S-EPMC7538228 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature