Positive Association of Human SHC3 Gene with Schizophrenia in a Northeast Chinese Han Population.

ABSTRACT:

Objective

Schizophrenia is one of the most devastating neuropsychiatric disorders. Genetic epidemiological studies have confirmed that schizophrenia is a genetic disease. Genes promoting neurodevelopment may be potential candidates for schizophrenia. As an adaptor linking a number of tyrosine kinase receptors in multiple intracellular signaling cascades, Src homology 2 domain containing transforming protein 3 (SHC3) is a member of the Shc-like adaptor protein family, and expressed predominantly in the mature neurons of the central nervous system (CNS). In the present study, we aimed to investigate the association of SHC3 and schizophrenia.

Methods

An independent case-control association study was performed in a sample including 710 schizophrenia patients and 1314 healthy con

SUBMITTER: Lv Y 

PROVIDER: S-EPMC7538253 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature