Hsp65-Producing Lactococcocus lactis Prevents Antigen-Induced Arthritis in Mice.

ABSTRACT: Oral tolerance is the physiological process that enables the immune system to differentiate between harmless dietary and microbiota antigens from pathogen derived antigens. It develops at the mucosal surfaces and can result in local and systemic regulatory and anti-inflammatory effects. Translation of these benefits to the clinical practice faces limitations involving specificity and doses of antigen as well as regimens of feeding. To circumvent these problems, we developed a recombinant Hsp65 delivered by the acid lactic bacteria Lactococcus lactis NCDO 2118 directy in the intestinal mucosa. Hsp65 is a ubiquitous protein overexpressed in inflamed tissues and capable of inducing immunoregulatory mechanisms. L. lactis has probiotic properties and is commonly and safely used in

SUBMITTER: Gusmao-Silva G 

PROVIDER: S-EPMC7538670 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature