Higher Body-Mass Index and Lower Gray Matter Volumes in First Episode of Psychosis.

ABSTRACT:

Background

Neurostructural alterations are often reported in first episode of psychosis (FEP), but there is heterogeneity in the direction and location of findings between individual studies. The reasons for this heterogeneity remain unknown. Obesity is disproportionately frequent already early in the course of psychosis and is associated with smaller brain volumes. Thus, we hypothesized that obesity may contribute to brain changes in FEP.

Method

We analyzed MRI scans from 120 participants with FEP and 114 healthy participants. In primary analyses, we performed voxel-based morphometry (VBM) with small volume corrections to regions associated with FEP or obesity in previous meta-analyses. In secondary analyses, we performed whole-brain VBM analyses.

Results

In primary

SUBMITTER: Kolenic M 

PROVIDER: S-EPMC7538831 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature