Antiviral activity of a novel mixture of natural antimicrobials, in vitro, and in a chicken infection model in vivo.

ABSTRACT: The aim of this study was to test in vitro the ability of a mixture of citrus extract, maltodextrin, sodium chloride, lactic acid and citric acid (AuraShield L) to inhibit the virulence of infectious bronchitis, Newcastle disease, avian influenza, porcine reproductive and respiratory syndrome (PRRS) and bovine coronavirus viruses. Secondly, in vivo, we have investigated its efficacy against infectious bronchitis using a broiler infection model. In vitro, these antimicrobials had expressed antiviral activity against all five viruses through all phases of the infection process of the host cells. In vivo, the antimicrobial mixture reduced the virus load in the tracheal and lung tissue and significantly reduced the clinical signs of infection and the mortality rate in the experimental group E2

SUBMITTER: Balta I 

PROVIDER: S-EPMC7538884 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature