Analysis of retinal sublayer thicknesses and rates of change in ABCA4-associated Stargardt disease.

ABSTRACT: Stargardt disease, the most common inherited macular dystrophy, is characterized by vision loss due to central retinal atrophy. Although clinical trials for Stargardt are currently underway, the disease is typically slowly progressive, and objective, imaging-based biomarkers are critically needed. In this retrospective, observational study, we characterize the thicknesses of individual retinal sublayers by macular optical coherence tomography (OCT) in a large cohort of patients with molecularly-confirmed, ABCA4-associated Stargardt disease (STGD1) relative to normal controls. Automated segmentation of retinal sublayers was performed with manual correction as needed, and thicknesses in various macular regions were compared using mixed effects models. Relative to controls (42 eyes, 40 patien

SUBMITTER: Whitmore SS 

PROVIDER: S-EPMC7538899 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature