Consistent opening of the blood brain barrier using focused ultrasound with constant intravenous infusion of microbubble agent.

ABSTRACT: The blood brain barrier (BBB) is a major obstacle to the delivery of therapeutics to the brain. Focused ultrasound (FUS) in combination with microbubbles can non-invasively open the BBB in a targeted manner. Bolus intravenous injections of microbubbles are standard practice, but dynamic influx and clearance mechanisms prevent delivery of a uniform dose with time. When multiple targets are selected for sonication in a single treatment, uniform serum concentrations of microbubbles are important for consistent BBB opening. Herein, we show that bubble infusions were able to achieve consistent BBB opening at multiple target sites. FUS exposures were conducted with different Definity microbubble concentrations at various acoustic pressures. To quantify the effects of infusion on BBB opening, we

SUBMITTER: Lapin NA 

PROVIDER: S-EPMC7538995 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature