Extensive fragmentation and re-organization of transcription in Systemic Lupus Erythematosus.

ABSTRACT: Systemic Lupus Erythematosus (SLE) is the prototype of autoimmune diseases, characterized by extensive gene expression perturbations in peripheral blood immune cells. Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the relationship between transcriptional deregulation and genome organization remains largely unstudied. In this work we propose a genomic approach that leverages patterns of gene coexpression from genome-wide transcriptome profiles in order to identify statistically robust Domains of Co-ordinated gene Expression (DCEs). Application of this method on a large transcriptome profiling dataset of 148 SLE patients and 52 healthy individuals enabled the identification of significant disease-associated

SUBMITTER: Ntasis VF 

PROVIDER: S-EPMC7539002 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature