Digital Cardiovascular Biomarker Responses to Transcutaneous Cervical Vagus Nerve Stimulation: State-Space Modeling, Prediction, and Simulation.

ABSTRACT:

Background

Transcutaneous cervical vagus nerve stimulation (tcVNS) is a promising alternative to implantable stimulation of the vagus nerve. With demonstrated potential in myriad applications, ranging from systemic inflammation reduction to traumatic stress attenuation, closed-loop tcVNS during periods of risk could improve treatment efficacy and reduce ineffective delivery. However, achieving this requires a deeper understanding of biomarker changes over time.

Objective

The aim of the present study was to reveal the dynamics of relevant cardiovascular biomarkers, extracted from wearable sensing modalities, in response to tcVNS.

Methods

Twenty-four human subjects were recruited for a randomized double-blind clinical trial, for whom electrocardiography and photoplethys

SUBMITTER: Gazi AH 

PROVIDER: S-EPMC7539162 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature