Regenerative Medicine and Angiogenesis; Challenges and Opportunities.

ABSTRACT: Blood vessel development is one of the most prominent steps in regenerative medicine due to the restoration of blood flow to the ischemic tissues and providing the rapid vascularization in clinical-sized tissue-engineered grafts. However, currently tissue engineering technique is restricted because of the inadequate in vitro/in vivo tissue vascularization. Some challenges like as transportation in large scale, distribution of the nutrients and poor oxygen diffusion limit the progression of vessels in smaller than clinically relevant dimensions as well in vivo integration. In this regard, the scholars attempted to promote the vascularization process relied on the stem cells (SCs), growth factors as well as exosomes and interactions of biomaterials with all of them to enable th

SUBMITTER: Jahani M 

PROVIDER: S-EPMC7539317 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature