Ontology highlight
ABSTRACT:
SUBMITTER: Shahryary Y
PROVIDER: S-EPMC7539454 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Genome biology 20201006 1
Stochastic changes in DNA methylation (i.e., spontaneous epimutations) contribute to methylome diversity in plants. Here, we describe AlphaBeta, a computational method for estimating the precise rate of such stochastic events using pedigree-based DNA methylation data as input. We demonstrate how AlphaBeta can be employed to study transgenerationally heritable epimutations in clonal or sexually derived mutation accumulation lines, as well as somatic epimutations in long-lived perennials. Applicat ...[more]