Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity.

ABSTRACT:

Background

The immune system undergoes a myriad of changes with age. While it is known that antibody-secreting plasma and long-lived memory B cells change with age, it remains unclear how the binding profile of the circulating antibody repertoire is impacted.

Results

To understand humoral immunity changes with respect to age, we characterized serum antibody binding to high density peptide microarrays in a diverse cohort of 1675 donors. We discovered thousands of peptides that bind antibodies in age-dependent fashion, many of which contain di-serine motifs. Peptide binding profiles were aggregated into an "immune age" by a machine learning regression model that was highly correlated with chronological age. Applying this regression model to previously-unobserved donors, we fou

SUBMITTER: Arvey A 

PROVIDER: S-EPMC7539520 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature